Practice Implications
Years ago, a group of researchers led by the late Larry Clark reported in a randomized, blinded trial that Se supplementation essentially cut the risk of prostate CA in half, an effect that was statistically significant. Interestingly, these exciting findings were published in JAMA, something that would hardly seem possible today.
The Clark trial was followed by evidence showing that high Se nutriture (as measured by toenail Se) is associated with a 65% reduced risk of developing advanced prostate CA.2 Other reports confirmed that higher Se status is linked with a reduced risk, though some investigations have not been able to confirm this relationship.
Follow-ups by Clark